Novel Optineurin Frameshift Insertion in a Family With Frontotemporal Dementia and Parkinsonism Without Amyotrophic Lateral Sclerosis

Frontotemporal Dementia (FTD) is a typical explanation for Younger Onset Dementia and has numerous scientific manifestations involving conduct, govt perform, language and motor perform, together with parkinsonism. As much as 50% of FTD sufferers report a constructive household historical past, supporting a robust genetic foundation, significantly in instances with each FTD and amyotrophic lateral sclerosis (FTD-ALS). Mutations in three genes are related to nearly all of familial FTD (fFTD) instances – microtubule related protein tau gene (MAPT), granulin precursor (GRN), and hexanucleotide repeat expansions in chromosome 9 open studying body 72- SMCR8complex subunit (C9orf72) whereas mutations in different genes similar to optineurin (OPTN) have hardly ever been reported.
Mutations in OPTN have been reported largely in familial and sporadic instances of ALS, or in uncommon instances of FTD-ALS, however not in affiliation with pure or predominant FTD and/or parkinsonian phenotype. Right here, we report for the primary time, a household from the Philippines with 4 members harboring a novel frameshift insertion at OPTN (Chr 10:13166090 G>GA) p.Lys328GluTer11, three of whom introduced with FTD-related phenotypes.
Moreover, one sibling heterozygous for the frameshift insertion had a predominantly parkinsonian phenotype resembling corticobasal syndrome, however it stays to be decided if this phenotype is said to the frameshift insertion. Notably, not one of the affected members confirmed any proof of motor neuron illness or ALS on the time of writing, each clinically and on electrophysiological testing, increasing the phenotypic spectrum of OPTN mutations. Shut follow-up of mutation carriers for the event of latest scientific options and wider investigation of further relations with additional genetic analyses might be carried out to analyze the potential for different genetic modifiers on this household which may clarify phenotypic heterogeneity.

Pulmonary AL amyloidosis and a number of myeloma presenting as cough with diffuse pulmonary opacities

Novel Optineurin Frameshift Insertion in a Family With Frontotemporal Dementia and Parkinsonism Without Amyotrophic Lateral Sclerosis
Amyloidosis is an unusual multisystem illness that may have an effect on many organs. Nevertheless, interstitial lung involvement could be very uncommon. A 68-year-old man introduced with long-standing dyspnoea and productive cough. After intensive investigation, together with two non-diagnostic bronchoscopies, a surgical lung biopsy demonstrated pulmonary amyloidosis. A bone marrow biopsy confirmed a number of myeloma. The affected person was handled with chemotherapy and an autologous stem cell transplant.

Crystal construction characterization and digital construction of a rare-earth-containing Zintl part within the Yb-Al-Sb household: Yb 3 AlSb 3

A rare-earth-containing compound, ytterbium aluminium antimonide, Yb3AlSb3 (Ca3AlAs3-type construction), has been efficiently synthesized inside the Yb-Al-Sb system via flux strategies. In keeping with the Zintl formalism, this construction is nominally made up of (Yb2+)3[(Al1-)(1b – Sb2-)2(2b – Sb1-)], the place 1b and 2b point out 1-bonded and 2-bonded, respectively, and Al is handled as a part of the covalent anionic community. The crystal construction options infinite corner-sharing AlSb4 tetrahedra, [AlSb2Sb2/2]6-, with Yb2+ cations residing between the tetrahedra to supply cost stability. Herein, the artificial situations, the crystal construction decided from single-crystal X-ray diffraction knowledge, and digital construction calculations are reported.

Remedy of AL Amyloidosis: Mayo Stratification of Myeloma and Danger-Tailored Remedy (mSMART) Consensus Assertion 2020 Replace

Immunoglobulin mild chain (AL) amyloidosis is a clonal plasma cell dysfunction resulting in progressive and life-threatening organ failure. The guts and the kidneys are probably the most generally concerned organs, however virtually any organ may be concerned. Due to the nonspecific presentation, prognosis delay is frequent, and plenty of sufferers are recognized with superior organ failure.
Within the period of efficient therapies and improved outcomes for sufferers with AL amyloidosis, the significance of early recognition is additional enhanced as the flexibility to reverse organ dysfunction is proscribed in these with a profound organ failure. As AL amyloidosis is an unusual dysfunction and given sufferers’ frailty and excessive early demise charge, administration of this advanced situation is difficult.
The remedy of AL amyloidosis is predicated on numerous anti-plasma cell therapies. These therapies are borrowed and customised from the remedy of a number of myeloma, a extra frequent dysfunction. Nevertheless, a rising variety of part 2/Three research devoted to the AL amyloidosis inhabitants are being carried out, making remedy selections extra evidence-based.
Supportive care is an integral a part of administration of AL amyloidosis due to the inherent organ dysfunction, limiting the supply of efficient remedy. This intensive evaluate brings an up to date abstract on the administration of AL amyloidosis, sectioned into the three pillars for survival enchancment: early illness recognition, anti-plasma cell remedy, and supportive care.

ALS-linked FUS mutants have an effect on the localization of U7 snRNP and replication-dependent histone gene expression in human cells

Genes encoding replication-dependent histones lack introns, and the mRNAs produced are a novel class of RNA polymerase II transcripts in eukaryotic cells that don’t finish in a polyadenylated tail. Mature mRNAs are thus fashioned by a single endonucleolytic cleavage that releases the pre-mRNA from the DNA and is the one processing occasion crucial. U7 snRNP is likely one of the key components that determines the cleavage web site inside the 3’UTR of replication-dependent histone pre-mRNAs.
We have now beforehand confirmed that the FUS protein interacts with U7 snRNA/snRNP and regulates the expression of histone genes by stimulating transcription and three’ finish maturation. Mutations within the FUS gene first recognized in sufferers with amyotrophic lateral sclerosis (ALS) result in the buildup of the FUS protein in cytoplasmic inclusions.

Amyotrophic Lateral Sclerosis 2 Chromosome Region 12 (ALS2CR12) Antibody (HRP)

abx334692-100g 100 µg
EUR 362.5

Amyotrophic Lateral Sclerosis 2 Chromosome Region 12 (ALS2CR12) Antibody (HRP)

abx334692-20g 20 µg
EUR 162.5

Amyotrophic Lateral Sclerosis 2 Chromosome Region 12 (ALS2CR12) Antibody (HRP)

abx334692-50g 50 µg
EUR 250

Amyotrophic Lateral Sclerosis 2 Chromosome Region 12 (ALS2CR12) Antibody (FITC)

abx334693-100g 100 µg
EUR 362.5

Amyotrophic Lateral Sclerosis 2 Chromosome Region 12 (ALS2CR12) Antibody (FITC)

abx334693-20g 20 µg
EUR 162.5

Amyotrophic Lateral Sclerosis 2 Chromosome Region 12 (ALS2CR12) Antibody (FITC)

abx334693-50g 50 µg
EUR 250

Amyotrophic Lateral Sclerosis 2 Chromosome Region 12 (ALS2CR12) Antibody (Biotin)

20-abx334694
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  • 100 ug
  • 1 mg
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  • 20 ug
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Amyotrophic Lateral Sclerosis 2 Chromosome Region 12 (ALS2CR12) Antibody (Biotin)

abx334694-100g 100 µg
EUR 362.5

Amyotrophic Lateral Sclerosis 2 Chromosome Region 12 (ALS2CR12) Antibody (Biotin)

abx334694-20g 20 µg
EUR 162.5

Amyotrophic Lateral Sclerosis 2 Chromosome Region 12 (ALS2CR12) Antibody (Biotin)

abx334694-50g 50 µg
EUR 250

Pig Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 11 protein(ALS2CR11) ELISA kit

E07A1410-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Porcine Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 11 protein(ALS2CR11) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 11 protein(ALS2CR11) ELISA kit

E07A1410-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Porcine Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 11 protein(ALS2CR11) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 11 protein(ALS2CR11) ELISA kit

E07A1410-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Porcine Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 11 protein(ALS2CR11) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 12 protein(ALS2CR12) ELISA kit

E07A1411-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Porcine Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 12 protein(ALS2CR12) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 12 protein(ALS2CR12) ELISA kit

E07A1411-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Porcine Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 12 protein(ALS2CR12) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 12 protein(ALS2CR12) ELISA kit

E07A1411-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Porcine Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 12 protein(ALS2CR12) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 protein(ALS2CR8) ELISA kit

E07A1412-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Porcine Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 protein(ALS2CR8) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 protein(ALS2CR8) ELISA kit

E07A1412-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Porcine Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 protein(ALS2CR8) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 protein(ALS2CR8) ELISA kit

E07A1412-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Porcine Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 protein(ALS2CR8) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Als2 (GFP-tagged) - Mouse amyotrophic lateral sclerosis 2 (juvenile) homolog (human) (Als2)

MG212062 10 µg Ask for price

Als2 (untagged ORF) - Rat amyotrophic lateral sclerosis 2 (juvenile) homolog (human) (Als2), (10 ug)

RN205048 10 µg Ask for price

HighQC™ Induced Pluripotent Stem Cell, From Amyotrophic Lateral Sclerosis

ABC-SC0211 1 vial Ask for price
Description: Amyotrophic Lateral Sclerosis donor, Derived from fibroblast, Passage number reprogrammed: 4, Passage Number: 26; Cells are only guaranteed with purchase of Gentaur Media and Gentaur Extra Cellular Matrix for appropriate cell culture, for 30 days from the date of shipment.

ALS2 (untagged)-Human amyotrophic lateral sclerosis 2 (juvenile) (ALS2), transcript variant 1

SC308723 10 µg Ask for price

ALS2 (untagged)-Human amyotrophic lateral sclerosis 2 (juvenile) (ALS2), transcript variant 2

SC325876 10 µg Ask for price

Guinea Pig Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 11 protein(ALS2CR11) ELISA kit

E01A35790 96T
EUR 700
Description: ELISA

Guinea Pig Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 12 protein(ALS2CR12) ELISA kit

E01A35791 96T
EUR 700
Description: ELISA

Guinea Pig Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 protein(ALS2CR8) ELISA kit

E01A35792 96T
EUR 700
Description: ELISA

Guinea pig Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 11 protein(ALS2CR11) ELISA kit

E05A1410-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Guinea pig Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 11 protein(ALS2CR11) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 11 protein(ALS2CR11) ELISA kit

E05A1410-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Guinea pig Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 11 protein(ALS2CR11) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 11 protein(ALS2CR11) ELISA kit

E05A1410-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Guinea pig Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 11 protein(ALS2CR11) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 12 protein(ALS2CR12) ELISA kit

E05A1411-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Guinea pig Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 12 protein(ALS2CR12) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 12 protein(ALS2CR12) ELISA kit

E05A1411-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Guinea pig Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 12 protein(ALS2CR12) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 12 protein(ALS2CR12) ELISA kit

E05A1411-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Guinea pig Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 12 protein(ALS2CR12) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 protein(ALS2CR8) ELISA kit

E05A1412-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Guinea pig Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 protein(ALS2CR8) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 protein(ALS2CR8) ELISA kit

E05A1412-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Guinea pig Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 protein(ALS2CR8) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 protein(ALS2CR8) ELISA kit

E05A1412-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Guinea pig Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 protein(ALS2CR8) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

ALS2 (GFP-tagged) - Human amyotrophic lateral sclerosis 2 (juvenile) (ALS2), transcript variant 2

RG226660 10 µg Ask for price

ALS2 (GFP-tagged) - Human amyotrophic lateral sclerosis 2 (juvenile) (ALS2), transcript variant 1

RG215448 10 µg Ask for price

Amyotrophic Lateral Sclerosis 2 Chromosomal Region Candidate Gene 2 Protein (ALS2CR2) Antibody

abx122767-100ug 100 ug
EUR 469.2

Amyotrophic Lateral Sclerosis 2 Chromosomal Region Candidate Gene 3 Protein (ALS2CR3) Antibody

abx037540-100ug 100 ug
EUR 469.2

Amyotrophic Lateral Sclerosis 2 Chromosomal Region Candidate Gene 3 Protein (ALS2CR3) Antibody

abx038241-100ug 100 ug
EUR 469.2

Amyotrophic Lateral Sclerosis 2 Chromosomal Region Candidate Gene 7 Protein (ALS2CR7) Antibody

abx033445-400ul 400 ul
EUR 627.6

Amyotrophic Lateral Sclerosis 2 Chromosomal Region Candidate Gene 7 Protein (ALS2CR7) Antibody

abx033445-80l 80 µl
EUR 343.2

Amyotrophic Lateral Sclerosis 2 Chromosomal Region Candidate Gene 4 Protein (ALS2CR4) Antibody

20-abx014186
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  • 100 ug
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Amyotrophic Lateral Sclerosis 2 Chromosomal Region Candidate Gene 8 Protein (ALS2CR8) Antibody

20-abx014187
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  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg

Amyotrophic Lateral Sclerosis 2 Chromosomal Region Candidate Gene 8 Protein (ALS2CR8) Antibody

abx230351-100ug 100 ug
EUR 577.2

Amyotrophic Lateral Sclerosis 2 Chromosomal Region Candidate Gene 1 Protein (ALS2CR1) Antibody

abx430786-200ul 200 ul
EUR 460.8

Amyotrophic Lateral Sclerosis 2 Chromosomal Region Candidate Gene 2 Protein (ALS2CR2) Antibody

abx430794-200ul 200 ul
EUR 460.8

Amyotrophic Lateral Sclerosis 2 Chromosomal Region Candidate Gene 3 Protein (ALS2CR3) Antibody

abx430795-200ul 200 ul
EUR 343.2

Amyotrophic Lateral Sclerosis 2 Chromosomal Region Candidate Gene 4 Protein (ALS2CR4) Antibody

abx014186-100g 100 µg
EUR 43.75

Amyotrophic Lateral Sclerosis 2 Chromosomal Region Candidate Gene 8 Protein (ALS2CR8) Antibody

abx014187-100g 100 µg
EUR 43.75

Amyotrophic Lateral Sclerosis 2 Chromosomal Region Candidate Gene 2 Protein (ALS2CR2) Antibody

abx122767-100l 100 µl Ask for price

Amyotrophic Lateral Sclerosis 2 Chromosomal Region Candidate Gene 2 Protein (ALS2CR2) Antibody

abx122767-20l 20 µl
EUR 337.5

Amyotrophic Lateral Sclerosis 2 Chromosomal Region Candidate Gene 2 Protein (ALS2CR2) Antibody

abx122767-50l 50 µl Ask for price

Amyotrophic Lateral Sclerosis 2 Chromosomal Region Candidate Gene 3 Protein (ALS2CR3) Antibody

abx037540-96tests 96 tests
EUR 337.5

Amyotrophic Lateral Sclerosis 2 Chromosomal Region Candidate Gene 3 Protein (ALS2CR3) Antibody

abx038241-100g 100 µg
EUR 337.5

Amyotrophic Lateral Sclerosis 2 Chromosomal Region Candidate Gene 7 Protein (ALS2CR7) Antibody

abx033445-100g 100 µg
EUR 250

Amyotrophic Lateral Sclerosis 2 Chromosomal Region Candidate Gene 8 Protein (ALS2CR8) Antibody

abx230351-100g 100 µg
EUR 350

Amyotrophic Lateral Sclerosis 2 Chromosomal Region Candidate Gene 1 Protein (ALS2CR1) Antibody

abx430786-200l 200 µl
EUR 387.5

Amyotrophic Lateral Sclerosis 2 Chromosomal Region Candidate Gene 2 Protein (ALS2CR2) Antibody

abx430794-200l 200 µl
EUR 387.5

Amyotrophic Lateral Sclerosis 2 Chromosomal Region Candidate Gene 3 Protein (ALS2CR3) Antibody

abx430795-200l 200 µl
EUR 387.5

Als2 (Myc-DDK-tagged ORF) - Rat amyotrophic lateral sclerosis 2 (juvenile) homolog (human) (Als2), (10 ug)

RR205048 10 µg Ask for price

ALS2 (Myc-DDK-tagged)-Human amyotrophic lateral sclerosis 2 (juvenile) (ALS2), transcript variant 2

RC226660 10 µg Ask for price

ALS2 (Myc-DDK-tagged)-Human amyotrophic lateral sclerosis 2 (juvenile) (ALS2), transcript variant 1

RC215448 10 µg Ask for price

Amyotrophic Lateral Sclerosis 2 Chromosomal Region Candidate Gene 13 Protein (ALS2CR13) Antibody

20-abx121963
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  • 100 ul
  • 200 ul
  • 30 ul

Amyotrophic Lateral Sclerosis 2 Chromosomal Region Candidate Gene 12 Protein (ALS2CR12) Antibody

20-abx148158
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  • Ask for price
  • 100 ug
  • 50 ug

Amyotrophic Lateral Sclerosis 2 Chromosomal Region Candidate Gene 16 Protein (ALS2CR16) Antibody

20-abx148159
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  • 100 ug
  • 50 ug

Amyotrophic Lateral Sclerosis 2 Chromosomal Region Candidate Gene 11 Protein (ALS2CR11) Antibody

20-abx014185
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  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg

Amyotrophic Lateral Sclerosis 2 Chromosomal Region Candidate Gene 13 Protein (ALS2CR13) Antibody

20-abx014188
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  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg

Amyotrophic Lateral Sclerosis 2 Chromosomal Region Candidate Gene 11 Protein (ALS2CR11) Antibody

20-abx307348
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  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Amyotrophic Lateral Sclerosis 2 Chromosomal Region Candidate Gene 11 Protein (ALS2CR11) Antibody

abx014185-100g 100 µg
EUR 43.75

Amyotrophic Lateral Sclerosis 2 Chromosomal Region Candidate Gene 13 Protein (ALS2CR13) Antibody

abx014188-100g 100 µg
EUR 43.75

Amyotrophic Lateral Sclerosis 2 Chromosomal Region Candidate Gene 11 Protein (ALS2CR11) Antibody

abx307348-100g 100 µg
EUR 362.5

Amyotrophic Lateral Sclerosis 2 Chromosomal Region Candidate Gene 11 Protein (ALS2CR11) Antibody

abx307348-20g 20 µg
EUR 162.5

Amyotrophic Lateral Sclerosis 2 Chromosomal Region Candidate Gene 11 Protein (ALS2CR11) Antibody

abx307348-50g 50 µg
EUR 250

Goat Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 protein(ALS2CR8) ELISA kit

E01A44510 96T
EUR 700
Description: ELISA

Rat Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 11 protein(ALS2CR11) ELISA kit

E02A1410-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Rat Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 11 protein(ALS2CR11) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 11 protein(ALS2CR11) ELISA kit

E02A1410-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Rat Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 11 protein(ALS2CR11) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 11 protein(ALS2CR11) ELISA kit

E02A1410-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Rat Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 11 protein(ALS2CR11) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 12 protein(ALS2CR12) ELISA kit

E02A1411-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Rat Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 12 protein(ALS2CR12) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 12 protein(ALS2CR12) ELISA kit

E02A1411-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Rat Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 12 protein(ALS2CR12) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 12 protein(ALS2CR12) ELISA kit

E02A1411-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Rat Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 12 protein(ALS2CR12) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 protein(ALS2CR8) ELISA kit

E02A1412-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Rat Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 protein(ALS2CR8) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 protein(ALS2CR8) ELISA kit

E02A1412-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Rat Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 protein(ALS2CR8) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 protein(ALS2CR8) ELISA kit

E02A1412-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Rat Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 protein(ALS2CR8) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 11 protein(ALS2CR11) ELISA kit

E01A9589 96T
EUR 700
Description: ELISA

Rat Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 12 protein(ALS2CR12) ELISA kit

E01A9590 96T
EUR 700
Description: ELISA

Rat Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 protein(ALS2CR8) ELISA kit

E01A9591 96T
EUR 700
Description: ELISA

Goat Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 protein(ALS2CR8) ELISA kit

E06A1412-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Goat Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 protein(ALS2CR8) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 protein(ALS2CR8) ELISA kit

E06A1412-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Goat Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 protein(ALS2CR8) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 protein(ALS2CR8) ELISA kit

E06A1412-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Goat Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 protein(ALS2CR8) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 11 protein(ALS2CR11) ELISA kit

E08A1410-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Canine Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 11 protein(ALS2CR11) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 11 protein(ALS2CR11) ELISA kit

E08A1410-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Canine Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 11 protein(ALS2CR11) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 11 protein(ALS2CR11) ELISA kit

E08A1410-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Canine Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 11 protein(ALS2CR11) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 12 protein(ALS2CR12) ELISA kit

E08A1411-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Canine Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 12 protein(ALS2CR12) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 12 protein(ALS2CR12) ELISA kit

E08A1411-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Canine Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 12 protein(ALS2CR12) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 12 protein(ALS2CR12) ELISA kit

E08A1411-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Canine Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 12 protein(ALS2CR12) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 protein(ALS2CR8) ELISA kit

E08A1412-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Canine Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 protein(ALS2CR8) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 protein(ALS2CR8) ELISA kit

E08A1412-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Canine Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 protein(ALS2CR8) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 protein(ALS2CR8) ELISA kit

E08A1412-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Canine Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 protein(ALS2CR8) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Als2cr11 (untagged) - Rat amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 11 (Als2cr11)

RN216914 10 µg Ask for price

ALS2CR8 (untagged)-Human amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 8 (ALS2CR8)

SC316965 10 µg Ask for price

ALS2CR8 (untagged)-Human amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 8 (ALS2CR8)

SC318208 10 µg Ask for price

ALS2CR8 (untagged)-Human amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 8 (ALS2CR8)

SC112033 10 µg Ask for price

ALS2CR8 (untagged)-Human amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 8 (ALS2CR8)

SC323963 10 µg Ask for price

Porcine Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 11 protein(ALS2CR11) ELISA kit

E01A53225 96T
EUR 700
Description: ELISA

Porcine Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 12 protein(ALS2CR12) ELISA kit

E01A53226 96T
EUR 700
Description: ELISA

Porcine Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 protein(ALS2CR8) ELISA kit

E01A53227 96T
EUR 700
Description: ELISA

Canine Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 11 protein(ALS2CR11) ELISA kit

E01A61943 96T
EUR 700
Description: ELISA

Canine Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 12 protein(ALS2CR12) ELISA kit

E01A61944 96T
EUR 700
Description: ELISA

Canine Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 protein(ALS2CR8) ELISA kit

E01A61945 96T
EUR 700
Description: ELISA

Monkey Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 11 protein(ALS2CR11) ELISA kit

E01A70655 96T
EUR 700
Description: ELISA

Monkey Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 12 protein(ALS2CR12) ELISA kit

E01A70656 96T
EUR 700
Description: ELISA

Monkey Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 protein(ALS2CR8) ELISA kit

E01A70657 96T
EUR 700
Description: ELISA

Mouse Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 11 protein(ALS2CR11) ELISA kit

E01A18331 96T
EUR 700
Description: ELISA

Mouse Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 12 protein(ALS2CR12) ELISA kit

E01A18332 96T
EUR 700
Description: ELISA

Mouse Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 protein(ALS2CR8) ELISA kit

E01A18333 96T
EUR 700
Description: ELISA

Goat Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 11 protein(ALS2CR11) ELISA kit

E01A44508 96T
EUR 700
Description: ELISA

Goat Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 12 protein(ALS2CR12) ELISA kit

E01A44509 96T
EUR 700
Description: ELISA

Rabbit Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 11 protein(ALS2CR11) ELISA kit

E01A27076 96T
EUR 700
Description: ELISA

Rabbit Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 12 protein(ALS2CR12) ELISA kit

E01A27077 96T
EUR 700
Description: ELISA

Rabbit Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 protein(ALS2CR8) ELISA kit

E01A27078 96T
EUR 700
Description: ELISA

Chicken Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 11 protein(ALS2CR11) ELISA kit

E01A88098 96T
EUR 700
Description: ELISA

Chicken Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 12 protein(ALS2CR12) ELISA kit

E01A88099 96T
EUR 700
Description: ELISA

Chicken Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 protein(ALS2CR8) ELISA kit

E01A88100 96T
EUR 700
Description: ELISA

Mouse Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 11 protein(ALS2CR11) ELISA kit

E03A1410-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Mouse Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 11 protein(ALS2CR11) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Right here, we report that mutations in FUS result in disruption of the transcriptional exercise of FUS and mislocalization of U7 snRNA/snRNP in cytoplasmic aggregates in mobile fashions and first neurons. As a consequence, decreased transcriptional effectivity and aberrant 3′ finish processing of histone pre-mRNAs have been noticed. This research highlights for the primary time the deregulation of replication-dependent histone gene expression and its involvement in ALS.

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